ICD-11

Non-Hodgkin lymphomas are characterised by a proliferation of predominantly large neoplastic B lymphocytes.

Primary diffuse large B-cell lymphoma is an aggressive tumor accounting for approximately 40% of the B-cell malignancies that presents with single or multiple rapidly enlarging, symptomatic masses in nodal or extranodal sites (stomach, central nervous system, bone, kidneys and testes).

An aggressive primary cutaneous B-cell lymphoma, usually involving the lower leg. It is composed of a generally monotonous proliferation of immunoblasts, or less frequently centroblasts, with few admixed reactive cells. This type of lymphoma occurs most often in the elderly who present with rapidly growing tumours, usually on one or both legs. Dissemination to extracutaneous sites is frequent.